With any road trip longer than 12 hours, consider beginning the drive at night. This is especially true if you’re traveling with young children.
The driver should, of course, sleep several hours before leaving, then begin the trip at the children’s bedtime. By driving while the children are asleep, you won’t need to take as many potty breaks, and the parents can enjoy a good portion of the ride without having to listen to children’s movies and songs.
Bonus: you’ll arrive at your destination when it’s daytime, so you won’t feel like a whole day has been wasted in the car.